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Name: David Chandler Phone: (08) 9361 5027
Email:
Websites: www.legioxxvi.net (MMORPG site); www.staticum.net (Business site coming soon). Course of Study: Doctor of Philosophy |
| Supervisors:; |
| Project
Title: |
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Expression,
Purification and Characterisation of the Recombinant Soluble
Receptor for Advanced Glycosylation End Products (sRAGE) |
| Brief
Project Summary |
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RAGE is a cell surface protein that is a member of the immunoglobulin
superfamily of molecules. RAGE interacts with a diverse repertoire
of circulating molecules including the glycoxidation products
(AGEs) that form during diabetes and the amyloid forming compounds
that are prevalent in Alzheimers disease. The consequence
of extended RAGE activation by AGEs and other molecules is
cell dysfunction and tissue destruction. In diabetes, this
leads to the progression of many of the complications of the
disease including macrovascular atherosclerosis, neuropathy
and retinopathy. RAGE ligation also promotes tumour metastasis
and invasion of surrounding tissue. Drug antagonists of RAGE
will therefore provide an outstanding therapeutic opportunity
for abaiting the progression of these diseases throught the
activities of this receptor. |
| Education: |
- Bachelor Science (Molecular Genetics, Distinction)
(Honours 1A)
- Master of I.T (Software Engineering) -O/G
(Monash University, Melbourne- Victoria)
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| Scholarships
/ Awards: |
- 1997 - Membership Golden Key Society
- 1999 - Graduated undergraduate' with distinction'
- 2000 - Russell Pathology Honours Scholarship
- 2000 - Bayer Top Honours Student Award
- 2004 - Australian Postgraduate Award
- 2004 - Curtin University Divisional (Health)
Scholarship Award
- 2004 - WABRI Macquarie Bank Postgraduate
Research Award and Scholarship
- 2004 - Schulten IAS Computational Biology
Workshop Scholarship
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| Publications: |
- Honours Thesis: Identification and characterisation
of a putative membrane component that modulates the binding
of insulin to its receptor, 2000, Curtin University
-
Bottomley, S., Chandler, D., Morgan, E., Helmerhorst, E. 2005 A New Computer-Based Integrated Molecular Visualization Learning Environment for University Students. Proceedings of the International Conference in Education. Singapore. pp 369-372
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| Interests: |
| RESEARCH
AREAS |
- Molecular visualisation software
- Computational biology applications and parallel computing
- Polycystic kidney disease - pathology and
treatment strategies
- Alzheimers Disease
- Rational drug design and clinical testing
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| PERSONAL
INTERESTS |
- Renovating and building houses
- web design
- Mechanics - car engines
- software design - Java mainly
- My Jack Russell Terriers... all three !
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