| |
| |
|
|
Name:
Misty-Lee Palmer
Phone: 08 9489 7859 (Lab)
Email: mistyp@ichr.uwa.edu.au
Course of Study: Doctor of
Philosophy |
| Supervisors: and |
| Project
Title: |
Investigating novel
drug resistance mechanisms in childhood acute lymphoblastic
leukaemia
|
| Project Description: |
Acute lymphoblastic leukaemia (ALL) is the most common
childhood cancer. Advances in chemotherapy treatments over
the last 20 years have resulted in 80% of patients being
cured. However the remaining 20% of patients suffer
relapses, related to drug resistance, and have a very poor
prognosis. Gene expression and drug resistance profiles of a
panel of 22 ALL cell lines were collected and used to
identify genes correlated with drug resistance. Top-ranked
genes are being functionally investigated to determine their
specific roles in drug resistance. The identification of
novel resistance mechanisms will be used to improve patient
survival by detecting patients at diagnosis who are at risk
of relapsing and would benefit from treatment with different
chemotherapy drugs.
|
| Education: |
- Bachelor of Science (Molecular Genetics) (Honours
1A), Curtin University of Technology
|
| Scholarships/Awards: |
- 2004-05 CSIRO Summer Vacation Scholarship
- 2005 Curtin University Postgraduate Scholarship
- 2006 Childrens Leukaemia and Cancer Research Foundation
Scholarship
|
| Publications: |
1. Honours thesis:
Optimising the expression of genes important for bioleaching
processes within iron-sulphur oxidising microbes. 2004,
Curtin University of Technology.
2. SE Keeling, M-L Palmer, FC Caracatsanis, JA Johnson and
HR Watling. 2005 Leaching of chalcopyrite and sphalerite
using bacteria enriched from a spent chalcocite heap.
Minerals Engineering, vol. 18, no. 13-14, pp. 1289-1296.
3. SE Keeling, KL Davies, M-L Palmer, DE Townsend, E Watkin,
JA Johnson and HR Watling. 2006 Utilisation of native
microbes from a spent chalcocite heap. Hydrometallurgy, vol.
83, pp. 124-131.
4. AH Beesley* and M-L Palmer*, J Ford, RE Weller, AJ
Cummings, JR Freitas, MJ Firth, KU Perera, NH de Klerk and
UR Kees. 2006 Authenticity and drug resistance in a panel of
acute lymphoblastic leukemia cell lines. British Journal of
Cancer, vol. 95, pp. 1537-1544
* Authors share equal-first authorship.
5. AH Beesley, M-L Palmer, J Ford, RE Weller, AJ Cummings,
JR Freitas, MJ Firth, KU Perera, NH de Klerk and UR Kees.
2006 In vitro cytotoxicity of Nelarabine, Clofarabine and
Flavopiridol in paediatric acute lymphoblastic leukaemia.
British Journal of Haematology. In press.
|
| Memberships: |
|
|
|
| |
|
|
|
|
|
|
