Beta-amyloid is the primary material
found in senile plaques of subjects with Alzheimer's
disease. Deposition occurs when insufficient chaperone
transporters of beta-amyloid are available. In
this program we have found that beta-amyloid is
produced by organs of the body other than the
brain in significant quanitites. Moreover, we
have identified novel transport molecules which
permit delivery to the brain. Our studies suggest
that cerebral deposits of beta amyloid may occur
as a result of exaggerated delivery to the brain
of beta amyloid which is produced elsewhere in
the body. In this project we are investigating
how to regulate non-cerebral beta-amyloid production.
Contact Details of Program Leader
Name: A/Prof John Mamo
Institution WABRI - Curtin University
Ph: +61 8 9266 7372
Fax: +61 8 9266 2958
Email:
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